Acetylcysteine Tables:

Pharmacokinetics

Bioavailability Peak plasma level Plasma half-life Active metabolites Elimination
minimal variability 5-10% 1 hour 2 to 6 hours none* partially renal
*Acetylcysteine is transformed to cysteine in the gut wall and the liver

Dose
Indication Administration
Initial loading dose
Dose Interval
Follow-up dose
Dose Interval
bronchitis oral 200 mg* 8 hours* 200 mg 12 hours
paracetamol intoxication intravenous First, 150 mg/kg in 15 minutes, then, 50 mg/kg in 4 hours, and finally, 100 mg/kg in 16 hours (in glucose 5%)
*Some manufacturers also recommend taking the entire daily dose at once

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