Pregnant women: Allowed despite certain doubts. No unequivocal danger has yet been demonstrated for children.

Nursing mothers: There are high concentrations in breast milk. It is better avoided.

Children: Oral administration: up to two years of age, half of the adult dose; older children take the adult dose. Intravenous administration: 3 X daily 250 mg (max. 500 mg) per m².

Elderly people: Mind the potential reduction of renal function.

Renal failure: Reduce the intravenous dose when the creatinine clearance (GFR) drops below 50 ml/min: GFR 25-50 ml/min: 5-10 mg/kg every 12 hours GFR 10-25 ml/min: 5-10 mg/kg every 24 hours GFR below 10 ml/min: 2.5-5 mg/kg/day Oral dose: Only reduce when GFR drops below 10 ml/min: 2 X daily 200 mg.

Liver insufficiency: No dose adjustment is necessary.

Table of Contents | Indications | Pharmacology | Adverse Reactions & Interactions | Contraindications & Cautions | References