Acyclovir Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
variable*
13-21%
2 hours
3 to 4 hours
none
renal
*Is absorbed gastrointestinally in an irregular fashion; no presystemic metabolism.
Dose
Indication
Administration
Initial loading dose
Dose
Interval*
Maintenence dose*
Dose*
Interval*
genital herpes simplex primary infection
oral
200 mg
4 to 5 hours
200 mg
4 to 5 hours
zoster of the cornea
oral
800 mg
4 to 5 hours
800 mg
4 to 5 hours
*Five times daily administration for 5 to 10 days. For
relapse prophylaxis
(frequently recurring herpes simplex infections): 2 X 400 mg/day.
Intravenous
(severe infections): 3 X 5-10 mg/kg daily.
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