Pregnant women: No teratogenic effects are known. Can be administered when indications are adequate.

Nursing mothers: Allopurinol and oxypurinol have been detected in breast milk. Only administer when absolutely necessary.

Children: Rarely indicated (enzyme disorders, cancer). Daily dose: 10 to 20 mg/kg, titrated according to uric acid level.

Elderly people: No dose reduction is necessary if renal function is normal.

Renal failure: Dose adjustment! Possible scheme: creatinine clearance less than 50 ml/min: 50% of the usual dose. Creatinine clearance less than 10 ml/min: 10 to 20% of the usual dose (alternative: greater intervals between doses).

Liver insufficiency: Reduce dose when insufficiency is advanced.

Table of Contents | Indications | Pharmacology | Adverse Reactions & Interactions | Contraindications & Cautions | References