Amoxycillin Tables:

Pharmacokinetics

Bioavailability Peak plasma level Plasma half-life Active metabolites Elimination
little variability 90% 1 to 2 hours 1 to 2 hours none renal
Effective levels are found in bronchial secretions, in the middle ear, in the bile, and to a lesser degree in cerebrospinal fluid, among others.

Dose
Indication Administration
Initial loading dose
Dose Interval
Maintenance dose
Dose Interval
uncomplicated cystitis oral 250-500 mg 8 hours* 250-500 mg 8 to 12 hours*
prevention of endocarditis oral 3 g 1 hour before intervention 750 mg** 6 hours**
*According to some studies the drug can also be administered every 12 hours (500-1000 mg/dose). The duration of the treatment must be established individually (usually longer for men).
**Only when risk of endocarditis is high: seven doses after the intervention.

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