Pregnant women: Several studies demonstrate an advantageous effect on pregnancy-associated hypertension. No known malformations. Mind bradycardias or hypoglycemia in the neonate!

Nursing mothers: Relatively high concentrations in breast milk. Metroprolol is less hazardous.

Children: Should not be used for children.

Elderly people: No multiplication of adverse reactions in elderly patients.

Renal failure: Considerably prolonged half-life! Dose adjustment: when plasma creatinine is above 300 µmol/l at the most 50 mg/day, when plasma creatinine is above 600 µmol/l: at the most 25-50 mg every other day.

Liver insufficiency: No dose adjustment is necessary.