Captopril Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
constant
60-65%
1 hour
2 hours
none*
predominantly renal
*Inactive metabolites are partially reconverted to active captopril.
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose
Interval
hypertension
oral*
12.5 mg
8 to 12 hours
12.5 to 50 mg
8 to 12 hours**
heart failure
oral*
6.25 mg
8 hours
12.5 to 50 mg
8 hours
*According to certain studies simultaneous food uptake decreases the bioavailability.
**In several studies captopril has been given successfully
once daily
for hypertension.
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