Pregnant women: Teratogenic effects are suspected (e.g. cleft spine), but other antiepileptic agents can be even riskier. Do not withdraw antiepileptic agents unpremeditatedly! The plasma levels normally decrease during pregnancy.

Nursing mothers: Carbamazepine and carbamazepine epoxide appear in small quantities in breast milk. Breast-feeding is permitted.

Children: Children metabolize carbamazepine quicker: half-life is 6 to 12 hours (for long-term treatment). Initial dose: twice daily 5 to 8 mg/kg; increase carefully.

Elderly people: Administer a small initial dose (100 mg twice a day).

Renal failure: Reduce regular dose by 25% when there is advanced insufficiency.

Liver insufficiency: Carefully monitor side-effects. Plasma level may have to be determined.