The symptoms of motion sickness (vertigo, nausea, vomiting) are successfully prevented and treated with cinnarizine. It has been tested on land, in the air and on sea in several (predominantly open) studies. In comparison with other antihistamines with similar effects (e.g. dymenhydrinate), it is said to be less sedative. However, there are no controlled comparisons.

Cinnarizine is also useful for vestibular symptoms of other origins. Clinical experiences and studies that have been made with the closely related flunarazine suggest the efficacy of cinnarizine. Methodically unobjectionable studies with cinnarizine are only available in small numbers. Studies that give accurate information on the relative efficacy for clinically defined syndromes such as Ménière's disease or cerebrovascular vertigo are particularly rare. There is also a lack of publicized comparisons between cinnarizine and flunarazine.

Despite the encouraging results from certain studies, the use of cinnarizine for peripheral arterial disease and migraine is doubtful. The drug does not entail improvement for senile dementia.

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