Cholecalciferol Tables:

Pharmacokinetics*

Bioavailability Peak plasma level Plasma half-life Active metabolites Elimination variable mostly good 4 hours 12-30 days calcitriol partially extrarenal

*The kinetics of cholecalciferol are poorly documented; the numbers refer to the (singly hydroxylized) metabolite calcifediol.

Dose

Indication Administration Initial loading dose Dose Interval Maintenance dose Dose Interval prevention of osteomalacia* oral 10 µg 24 hours 10-20 µg 24 hours

*When there is an insufficient dietary vitamin D uptake and/or insufficient sun exposure. Is often given in combination with calcium supplements.

Copyright © 1996 Infomed-Verlags AG