Codeine Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
moderate variability
50%
1 hour
3 to 4 hours
several
predominantly extrarenal
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose*
Interval
dry cough**
orally
10-20 mg
6 hours
10-30 mg
6 hours
pain**
orally
15-30 mg
4 to 6 hours
15-60 mg
6 hours
*Dependence can result from long-term codeine administration (especially from high doses).
**All numbers refer to non-slow-release tablets.
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