Cyclophosphamide Tables:

Pharmacokinetics

Bioavailability Peak plasma level Plasma half-life Active metabolites Elimination
little variability > 75% 1 hour 4 to 10 hours important* predominantly renal**
*The effect of the drug is based on its metabolites which also have short half lives.
**40% or more are excreted through the stool following oral administration.

Dose
Indication Administration Dosage
antineoplastic chemotherapy oral or parenteral individual, mostly cyclic (with two-week breaks), e.g. initially 1-5 mg/kg/day per os.
autoimmune diseases (e.g. lupus nephritis) oral or parenteral short-term/interrupted ("pulse therapy"), e.g. 500 to 100 mg/m2 monthly i.v.

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