Diclofenac causes gastrointestinal ailments (upper abdominal and gastric pain, nausea, vomiting, diarrhea or constipation) in more than 5% of the treated subjects. Approximately 2% must discontinue the drug due to the above reasons. Headaches, vertigo and sleep disturbances are also observed occasionally.

Hematological problems (e.g. granulocytopenia), increased liver enzymes, exanthemas and renal function disorders are less frequent.

Dangerous reactions such as bleeding gastric ulcers, perforations, hepatitis and renal failure are rare.

Dangerous reactions such as bleeding gastric ulcers, perforations, hepatitis, renal failure are rare.

Patients with pre-existing heart failure, hypertension or renal failure are more prone to the development of renal function disorders and should be observed closely after the beginning of the treatment.

Diclofenac: Interactions

Just like other antirheumatic agents, diclofenac can reduce the efficacy of antihypertensive drugs and it can increase the toxicity of lithium and methotrexate. Despite its platelet inhibiting effect, diclofenac can be administered (with great care) in combination with anticoagulants.

Table of Contents | Indications | Pharmacology | Contraindications & Cautions | Risk Groups | References