The efficacy of diclofenac as an anti-inflammtory agent and analegesic is well documented: in comparison with many other anti-inflammatory agents (e.g. ibuprofen, indomethacin, naproxen, piroxicam) diclofenac has proven to be about equal. The differences that have been observed in some studies are generally based on the use of doses with different therapeutic activity. Among the documented indications the following stand out: chronic polyarthritis, ankylosing spondilytis, osteoarthritis, gout attacks, extra-articular rheumatism, post-traumatic and postoperative pain, and dysmenorrhea. Like other non-steroidal anti-inflammatory agents, diclofenac only produces a symptomatic effect.

Intramuscular injection of diclofenac is not only efficient for pain in the musculoskeletal system, but also e.g. for ureter and biliary colics. In such cases, the drug can be equally as efficient as a combination of opioids and spasmolytics and is better tolerated.

Diclofenac is also available in ointments and gels (like other anti-inflammatory agents). The use of such preparations is partially based on the placebo effect. Finally, diclofenac is also available in the form of eye drops for application after cataract operations.

Table of Contents | Pharmacology | Adverse Reactions & Interactions | Contraindications & Cautions | Risk Groups | References