Diclofenac Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
constant
50-60%
1 hour*
1 to 2 hours
none
predominantly hepatic
*If taking forms resistant to gastric juices the peak plasma level is only reached after 2 to 3 hours.
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose
Interval
pains of different causes
oral
50 mg
8 hours
25-50 mg*
8 hours*
acute pains
i.m.
75 mg
12 hours
-
-
*For long-term treatment slow-release preparations are more suitable (75 mg every 12 hours or 100 mg every 24 hours).
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