Digoxin Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
relatively constant*
50-60%
4 to 6 hours
40 hours (20 to 50 hours)
probably of little importance
renal
*There are, however, significant differences between the individual digoxin preparations!
Dose
Indication
Administration
Initial loading dose (1 to 3 days)*
Dose
Interval
Maintenance dose
Dose
Interval
tachycardial atrial fibrillation
oral
0.25 mg
8 hours
0.25 mg (0.125 to 0.5 mg)
24 hours
emergency therapy
i.v.
0.125 mg to 0.5 mg
6 hours
-
-
*The initial saturation level can also be reached slowly and more safely with maintenance doses.
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