Diltiazem Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
variable*
40%
2 to 4 hours
4 to 5 hours
yes
extrarenal
*Pronounced presystemic metabolism. Bioavailability increases with higher doses!
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose
Interval
angina, hypertension
oral
30-60 mg
6 to 12 hours
90-180 mg
12 hours*
emergencies (e.g. hypertension)
i.v.
0.25 mg/kg**
30 minutes
-
-
*This data refers to slow-release tablets; Dilzem RR (180 mg) is taken once daily.
**Inject slowly; a delayed injection is possible (5-15 mg/hour, maximum of 300 mg/24 hours).
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