Pregnant women: Contraindicated. Disturbances in the development of the teeth and bones of the fetus. Can be hepatotoxic for the mother in isolated cases.

Nursing mothers: Most specialists allow breast-feeding: it appears only in small amounts in breast milk; risks for child and mother are probably minimal.

Children: Contraindicated before the age of eight! (staining of the teeth and possibly disturbed bone growth.) Older children: 2 to 4 mg/kg/day, maybe divided into two doses.

Elderly people: No dose adjustment is necessary.

Renal failure: Some authors recommend a dose reduction when there is severe insufficiency.

Liver insufficiency: No dose adjustment necessary.

Table of Contents | Indications | Pharmacology | Adverse Reactions & Interactions | Contraindications & Cautions | References