Doxycycline Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
variable*
95%
2 to 3 hours
14 to 24 hours
none
partially renal
Good penetration of the various tissues and body fluids.
*Absorption is only marginally reduced (by a maximum of 20%) by milk or food.
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose*
Interval
acne
oral
25-50 mg
24 hours
25-50 mg
24 hours
chlamydia infections
oral
100-200 mg
24 hours
100-200 mg
24 hours
*The duration of treatment depends on the diagnosis; for most infections doxycycline can be dosed as in the above examples for chlamydia infections.
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