Erythromycin: Risk Groups

Pregnant women:
Use is considered safe. Increased transaminase values and hepatitis potential during pregnancy.

Nursing mothers:
Relatively large amounts have been found in breast milk but it can be given. Hypersensitivity and alteration of the intestinal flora are possible in the infant.

Children:
Daily dose: 30 to 50 mg/kg; a maximum of 100 mg/kg/day for severe infections.

Elderly people:
No dose adjustment is necessary if liver functions are normal.

Renal failure:
There might be an increased risk of ototoxic effects. Some authors recommend a reduction of the dose by 50% when there is advanced renal failure.

Liver insufficiency:
Considering its potential hepatotoxicity, it is better to avoid erythromycin when a liver disorder is indicated.

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