Pregnant women: Even though no teratogenic effects are known, it is not recommended to use sulphonylureas due to the risk of abnormal blood glucose levels in the child; insulin is used instead.

Nursing mothers: Risk of hypoglycemia for the neonate: weaning or insulin instead of glibenclamide.

Children: No indication. Diabetes generally requires insulin treatment in children and youths. Young children: accidental taking of several tablets is life threatening!

Elderly people: Increased risk of hypoglycemia. Initial doses should be kept low, increase dose slowly. Better avoided in old age.

Renal failure: A dose reduction is recommended for moderate insufficiency. It is contraindicated for advanced insufficiency.

Liver insufficiency: Very cautious dosage (risk of hypoglycemia!); contraindicated when insufficiency is advanced.

Table of Contents | Indications | Pharmacology | Adverse Reactions & Interactions | Contraindications & Cautions | References