Ketoconazole Tables:

Pharmacokinetics

Bioavailability Peak plasma level Plasma half-life Active metabolites Elimination
variable* 75% 2 to 3 hours 6 to 10 hours none extrarenal
*Resorption is dependent on the pH of the stomach content (favoured by acids); ketoconazole is also metabolized presystemically.

Dose
Indication Administration
Initial loading dose
Dose Interval
Maintenance dose
Dose* Interval
chronic mucocutaneous candidiasis oral 200 mg 24 hours 100-400 mg 24 hours
*Most indications require a duration of treatment of 2 weeks to many months. For vaginal candidosis the treatment (400 mg/day) should be limited to three days. However, if possible, topical use should be given preference to the more hazardous systemic administration.

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