Levothyroxine Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
variable
50-80%
2 to 4 hours
7 days
tri-iodothyronine*
partially renal
*About 40% of the levothyroxine dose is metabolized to tri-iodothyronine in the liver and the kidneys.
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose
Interval
hypothyroidism
oral
50-100 µg*
24 hours
10-150 µg*
24 hours
*Average dose: 1.6 µg per kilo: men therefore normally need slightly higher doses than women. Best taken 30 minutes before breakfast.
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