Metoclopramide Tables:

Pharmacokinetics

Bioavailability Peak plasma level Plasma half-life Active metabolites Elimination
variable* 50% (30-90%) 1 to 2 hours 4 hours (3 to 5 hours) unknown predominantly renal
*Presystemic metabolism is different from individual to individual.

Dose
Indication Administration
Initial loading dose
Dose Interval
Maintenance dose
Dose Interval
nausea/vomiting oral 10 mg 8 hours 5-10 mg* 6 to 8 hours*
strong emetogenic chemotherapy i.v. 2 mg/kg 2 hours** 1-2 mg/kg 3 hours**
*Metoclopramide must not be administered in the long term!
**First intravenous infusion one hour before chemotherapy, then repeated twice after two hours, consequently another two or three times every three hours. For optimal results corticosteroids (e.g. dexamethasone) and a benzodiazepine or an antihistamine are added.

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