Pregnant women: Even though there are no clear indications of teratogenic effects, metronidazole ought to be avoided in the first trimester.

Nursing mothers: Relatively high concentrations in breast milk (like in plasma), it should therefore be avoided. Nursing possible 24 hours after a single dose.

Children: Daily dose: 20-40 mg/kg, divided in three doses. Neonates: initially 15 mg/kg, later 7.5 mg/kg/day (i.v.).

Elderly people: Caution with neurological diseases (risk of cramps). Generally no dose adjustment necessary.

Renal failure: Dose reduction recommended because of biologically active metabolite.

Liver insufficiency: Increase of plasma levels likely because of the predominantly hepatic metabolism. Reduce dose!

Table of Contents | Indications | Pharmacology | Adverse Reactions & Interactions | Contraindications & Cautions | References