Pregnant women: Methadone is less problematic than illegal drugs. Nevertheless, the impact on the child is considerable: withdrawal syndrome in the neonate; long-lasting effects cannot be excluded.

Nursing mothers: Methadone is excreted through breast milk; doses of up to 20 mg/day do not seem to cause any problems. Effects are possible if doses are higher.

Children: Increased risk of respiratory depression in infants. Childrens' dose for severe pain: 0.2 mg/kg every 6 hours. Adult doses are life-threatening.

Elderly people: Begin with the smallest doses; increased risk of respiratory depression.

Renal failure: Reduce dose by 50% or increase interval when there is advanced failure.

Liver insufficiency: Half-life is only prolonged if there is severe cirrhosis: reduce dose!

Table of Contents | Indications | Pharmacology | Adverse Reactions & Interactions | Contraindications & Cautions | References