Even though methotrimeprazine can be used for the treatment of schizophrenia like other neuroleptic agents, it is often used on non-psychotic patients. Thanks to its strong sedative effect in small doses, it is well suitable for the treatment of anxiety states. Whether it really differs from other sedative neuroleptic agents in this respect has not yet been documented in controlled studies.

In the USA, methotrimeprazine is approved expressly as an injection for the treatment of pain. But even this indication is not based on controlled studies; the analgesic effect (which is similar to that of opiates) may at least in part be explained with the sedation. Just like methotrimeprazine, other neuroleptic agents, e.g. chlorprothixen, can be elements of a therapy plan for obstinate pain. However, it would be desirable to establish more closely the relative benefits of these drugs e.g. for cancer patients.

Methotrimeprazine as a nightly sedative (for subjects without psychotic diseases) has not yet been adequately compared to benzodiazepines.

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