Methotrimeprazine Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
little variability
50%*
1 to 3 hours
15 to 30 hours
probable
predominantly extrarenal
*Presystemic metabolism is probable. Numerous metabolites whose pharamaceutic activity is not clearly established.
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose
Interval
anxious restlessness
oral
5-15 mg*
24 hours*
5-50 mg
12 to 24 hours
adjuvant for pain
i.m.
12.5-25 mg
8 hours
12.5-50 mg
8 hours
*In most cases,
one
nightly dose is sensible. If the drug is given during the day the first dose can be even smaller.
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