The most common adverse reactions are gastrointestinal pains (heartburn, abdominal pain, nausea, constipation, all occur in more than 5% of treated subjects). Central nervous problems such as headaches, somnolence, tinnitus, vertigo, as well as edemas and respiratory problems, are not uncommon either.

Skin rashes, pruritus, diarrhea, insomnia, depressions, myalgias etc. are not observed very frequently with naproxen.

Dangerous side-effects (gastrointestinal bleedings or perforations, acute interstitial nephritis, hepatitis, blood production disorders) are rare.

Naproxen: Interactions

Like other anti-inflammatory agents, naproxen can impair the hypotensive effect of antihypertensive agents and it can increase the toxicity of methotrexate. Naproxen can also cause a rise in lithium levels. On the other hand, probenecid significantly prolongs the half-life of naproxen. Despite the fact that it can inhibit platelet aggregation, naproxen can be combined with anticoagulants (if monitored carefully).

Table of Contents | Indications | Pharmacology | Contraindications & Cautions | Risk Groups | References