Naproxen Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
constant
99%
2 to 4 hours*
12 to 15 hours
none
predominantly extrarenal
*Naproxen sodium is absorbed more quickly; peak plasma levels are reached after 1 to 2 hours.
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose
Interval
acute rheumatic pain in the joints
oral
500-750 mg*
12 hours
250-500 mg*
12 hours
other pains
oral
250-500 mg*
12 hours
250-500 mg*
12 hours
*Sodium salt (naproxen sodium) is dosed 10% higher (e.g. 550 mg instead of 500 mg).
The drug is also available for rectal administration and naproxen sodium for intramuscular injection.
Copyright © 1996 Infomed-Verlags AG