Paracetamol Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
constant
80%
40 to 60 minutes
2 to 3 hours
none
predominantly extrarenal
Bioavailability is significantly lower when the drug is administered rectally.
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose*
Interval
pains of all kinds
oral
500 mg
4 to 6 hours
250-1000 mg
4 to 6 hours
*Many specialists advise against chronic use of analgesics. As the risk of nephropathy cannot be totally excluded, this is also valid for paracetamol as a single substance.
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