Pregnant women: Can be given. Penicillin is considered the safest antibiotic during pregnancy.

Nursing mothers: Can be given. Concentrations in breast milk are relatively low. The risk of an alteration of the child's intestinal flora or of a hypersensitization cannot be excluded.

Children: Intravenously for severe infections: 0.2 to 0.5 million U/kg/day in 4 to 6 doses. Oral (penicillin V): 100,000 U/kg/day in two doses (a maximum of 1.5 million U/day).

Elderly people: No dose reduction is necessary if renal functions are normal.

Renal failure: Creatinine clearance less than 50 ml/min: reduce dose by 25 to 50%; clearance less than 10 ml/min: reduce dose by 50-75%.

Liver insufficiency: No dose adjustment necessary.

Table of Contents | Indications | Pharmacology | Adverse Reactions & Interactions | Contraindications & Cautions | References