Our Comment:
Propranolol is not a particularly practical beta-blocker because of the great individual differences of metabolism. I therefore only rarely use this substance for hypertension and coronary heart disease. On the other hand, there is hardly a beta-blocker that is as thoroughly documented as propranolol, particularly for special indications (hyperthyroidism, migraine, portal hypertension). In these cases propranolol still is the beta-blocker of choice.