Propranolol Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
variable*
5-50%
1 to 2 hours
3 to 6 hours
little importance
predominantly hepatic
*Pronounced, individually different presystemic metabolism.
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose
Interval
angina pectoris or arterial hypertension
oral
10-40 mg
8 hours
40-160 mg
8 to 12 hours*
arrhythmias
i.v.
0.5-3 mg
2 minutes**
*Slow release preparations, which only have to be given once daily, are suitable for long-term therapy.
**Intravenous injection must occur slowly (maximum 1 mg/min), only one repetition.
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