Ranitidine Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
variable*
50% (40-80%)
2 to 3 hours
2 to 3 hours**
none (?)
predominantly renal
*Presystemic metabolism
**The effect, however, lasts longer, e.g. about 5 hours with a 150 mg dose.
Dose
Indication
Administration
Initial loading dose
Dose
(for 4 to 8 weeks)
Interval
Maintenance dose
Dose (prophylaxis)
Interval
gastro-duodenal ulcers
oral
150 mg*
12 hours*
150 mg
24 hours
erosive esophagitis
oral
150 mg
6 to 8 hours
150 mg
12 hours
*Alternative: Single dose of 300 mg/day before retiring to bed.
Intravenously: 50 mg every 6 to 8 hours (in injection solutions of at least 20 ml;
slow
injection).
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