Simvastatin Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
little variability
<5%
1 to 2 hours
not determined
present
partially renal
All data refer to the principal active metabolite of simvastatin (simvastatin acid). Simvastatin is well absorbed after taking orally and it is immediately metabolised to simvastatin acid in the liver.
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Follow up dose
Dose
Interval
familial hypercholesterolemia
oral
5-10 mg
24 hours*
5-40 mg
24 hours*
*Some manufacturers also recommend taking the entire daily dose at once
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