Spironolactone has a dose-dependent effect on the function of the sexual hormones: in the long run gynecomastia occurs in more than 10% (in more than half with doses of 150 mg/day) of the treated men. Impotence, loss of libido and menstrual irregularities are not uncommon.

In more than 5% of the treated subjects a hyperkalemia develops (especially if renal functions are impaired, in diabetics, and the elderly). Hyponatremia, reduced renal functions and skin reactions (e.g. urticaria) are rare.

Hematologic anomalies, gastric ulcers and hepatitis are rare as well.

Spironolactone: Interactions

Concomitant administration of other potassium-sparing diuretics (amiloride, triamterene) and potassium salts, as well as ACE inhibitors, can cause dangerous hyperkalemia.

Table of Contents | Indications | Pharmacology | Contraindications & Cautions | Risk Groups | References