Pregnant women: No malformations are documented in humans. However, in view of the anti-androgenic effect, spironolactone is better avoided.

Nursing mothers: The metabolite canrenone can be traced in small amounts in breast milk. The manufacturer recommends weaning or avoidance.

Children: Usual dose: 1-2 mg/kg/day (rarely indicated).

Elderly people: Mind risk of hyperkalemia if renal functions are reduced!

Renal failure: Contraindicated for any form of advanced or quickly progressing renal failure!

Liver insufficiency: For the timely recognition of a metabolic acidosis, the plasma bicarbonate levels ought to be monitored from time to time.

Table of Contents | Indications | Pharmacology | Adverse Reactions & Interactions | Contraindications & Cautions | References