Tamoxifen Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
unknown
4 to 7 hours
7 days*
important*
predominantly renal
*One of the active metabolites (desmethyltamoxifen) has a half-life of 14 days.
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose
Interval
adjuvant therapy of breast cancer
oral
20 mg
24 hours
20 mg*
24 hours*
metastasizing forming breast cancer
oral
20 mg
24 hours
20-40 mg**
24 hours
*Adjuvant tamoxifen therapy is given continuously for 5 years if there is no rebound.
**If there is no response, the dose may be increased to 40 mg/day after 4 weeks.
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