*Data for quickly absorbable preparations; slow release preparations reach their maximum about 4-5 hours after administration.
**Great inter-and intra-individual differences. Average values: premature neonates 30 hours, infants younger than 6 months 12 hours, younger than 1 year 5 hours, children between 1 and 17 years 3-4 hours, adults 8 hours (smokers 4-5 hours).
*Administration of a slow-release preparation before retiring to bed. Increase
dose slowly!
**A single loading dose for patients who had not received theophylline before. Slow injection! (preferably over 20 to 30 minutes) Aminophylline (6 mg/kg) can be given instead of theophylline.