Timolol Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
variable
30-50%
1 to 2 hours
3 to 5 hours
probably none
predominantly extrarenal
Pronounced presystemic metabolism, determined genetically (debrisoquine polymorphism).
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose
Interval
glaucoma
eye drops (0.25%)
1 drop
12 hours
1 drop*
12 to 24 hours
hypertension
oral
10 mg
24 hours
5-30 mg
12 to 24 hours
*If effect is not sufficient, drops with higher concentration (0.5%) can be used.
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