Dexamethasone: Risk Groups

Pregnant women:
In animal experiments high doses have teratogenic effects. However, it can be given when indications are unambiguous. For the prevention of respiratory distress syndrome: 12 mg/day, 1 week before birth.

Nursing mothers:
Is probably eliminated through breast milk. Even if the amounts are probably marginal, most specialists recommend weaning.

Acute therapy, depending on the indication for 1 to 5 days: 0.6 to 1.0 mg/kg/day, divided in 2 to 4 doses. Avoid long-term administration.

Elderly people:
Begin with the smallest initial dose. There is a high risk of side-effects accompanying long-term treatment (osteoporosis, diabetes, hypertension).

Renal failure:
Dose adjustment is probably not necessary (metabolism is accelerated).

Liver insufficiency:
When there is advanced insufficiency a dose reduction by 50% is indicated.

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