Dextromethorphan Tables:
Pharmacokinetics
Bioavailability
Peak plasma level
Plasma half-life
Active metabolites
Elimination
great variability
< 1%
2 hours
3 to 4 hours
very important
partially renal
All numbers refer to the kinetics of dextromethorphan in fast metabolizers. The antitussive effect is probably based on the main metabolite (dextrorphan) which is predominantly excreted renally.
Dose
Indication
Administration
Initial loading dose
Dose
Interval
Maintenance dose
Dose
Interval
cough
oral
20-30 mg
6 to 8 hours
-
-
Copyright © 1996 Infomed-Verlags AG